*A chronic inflammatory condition caused by an autoimmune disease. An autoimmune disease occurs when the body's tissues are attacked by its own immune system. Patients with lupus have unusual antibodies in their blood that are targeted against their own body tissues.
*Lupus can cause disease of the skin, heart, lungs, kidneys, joints, and nervous system.
*When internal organs are involved, the condition is Lupus SLE
Mixed Connective Tissue Disease
*Mixed connective tissue disease has signs and symptoms of a combination of disorders — primarily lupus, scleroderma and polymyositis. For this reason, mixed connective tissue disease is sometimes referred to as an overlap disease.
*In mixed connective tissue disease, the symptoms of the separate diseases usually don't appear all at once. Instead, they tend to occur in sequence over a number of years, which can make diagnosis more complicated.
Membranous Lupus Nephritis
*Lupus nephritis is a spectrum of immune complex-mediated renal diseases occurring in patients with the diagnosis of systemic lupus erythematosus (SLE).
*In class V lupus nephritis, the predominant pattern of glomerular injury is membranous, characterized by formation of subepithelial electron-dense deposits, in the absence of endocapillary or extracapillary proliferative changes; clinically, there is heavy proteinuria, with or without nephrotic syndrome.
*A chronic inflammatory skin condition that is limited to the chronic skin eruptions and is caused by an autoimmune disease. It favors the face, ears, and scalp and at times on other body areas. *When only the skin is involved, the condition is Lupus DLE